Source plot synopsis — includes the ending
The ensuing love triangle soon leads Keiko to seek the assistance of her father who, unbeknownst to his daughter, moonlights as a Kabuki-clad mad scientist with the school nurse as his assistant. The pair experiment on students in the school basement, hoping to discover the secret of reanimating corpses in a matter akin to the work of the fictional mad scientist, Victor Frankenstein.
Their hopes are soon answered when they discover a solution of Monami's blood holds the properties to bring life to dead body parts and inanimate objects.
The story begins to unfold after Mizushima carelessly accepts a honmei choco spiked with Monami's blood, turning him into a half vampire. When Keiko discovers their secret, she attacks Monami but accidentally throws herself off the school roof in the process. Her premature death leads to her father using the blood solution to transform her into a vicious Frankenstein's monster determined to get revenge against Monami.
From then on, Monami and Keiko battle each other in the pursuit of winning Mizushima's heart, regardless of his feelings towards either of them. Monami ultimately kills her archrival by ripping the flesh off the latter's body using droplets of her own blood to form spikes and impaling her skeletal corpse on top of Tokyo Tower.
At the end, Keiko's father turns himself in a Franken Advanced Composite Life Form with use of Monami's blood, and it is revealed that Igor was turned into a vampire by Monami a hundred years ago, and that Mizushima is only one in a long succession of boyfriends.
Sources and content license
Source and revision history ↗ · Adapted from Wikipedia contributors, Vampire Girl vs. Frankenstein Girl. Section headings and formatting adjusted. · Content license