Resident Evil Requiem

=== Setting ===
The story of Requiem is set in October 2026, 28 years after the destruction of Raccoon City. It follows FBI intelligence analyst Grace Ashcroft (Angela Sant'Albano / Shihori Kanjiya), the daughter of Resident Evil Outbreak (2003) protagonist Alyssa Ashcroft (Jane Perry / Kikuko Fujimoto), and, secondarily, Division of Security Operations (DSO) agent Leon S. Kennedy (Nick Apostolides / Toshiyuki Morikawa), a protagonist introduced in Resident Evil 2. Capcom described Grace as an introverted bookworm who feels powerless due to not being proficient in combat, unlike Resident Evil protagonists such as Claire Redfield or Jill Valentine. Leon is supported by Sherry Birkin (Eden Riegel / Maaya Sakamoto), a fellow DSO agent whom he rescued from Raccoon City's destruction when she was a child. Grace also encounters Emily (Emma Rose Creaner / Misa Segawa), a blind girl who was taken captive and experimented on.
Grace and Leon are opposed by Victor Gideon (Antony Byrne / Yutaka Aoyama), a former Umbrella Corporation scientist seeking to carry out the will of its deceased founder Oswell E. Spencer (James Clyde / Ryūsei Nakao), and Zeno (Craig Burnatowski / Shunsuke Takeuchi), an agent of the Connections crime syndicate who resembles Albert Wesker. Major locations include the condemned Wrenwood Hotel, the Rhodes Hill Chronic Care Center, and the ruins of Raccoon City.



Plot

FBI analyst Grace Ashcroft investigates mysterious deaths among survivors of the Raccoon City incident caused by lingering T-virus mutations known as Raccoon City Syndrome (RCS). She is assigned to inspect a victim discovered in the derelict Wrenwood Hotel, where her mother, Alyssa, was murdered eight years earlier. Inside the hotel, Grace recovers a data disk left by Alyssa. She is abducted by former Umbrella scientist Victor Gideon, who has been searching for her. DSO agent Leon Kennedy, who is suffering from RCS, separately investigates the deaths. He arrives and sees Victor, who infects nearby civilians with the T-virus, triggering a zombie outbreak that allows him to escape with Grace to the Rhodes Hill Chronic Care Center. Leon's handler, Sherry Birkin, helps track Victor's location.
Grace awakens in Rhodes Hill and escapes confinement, but is stalked by a giant mutant known as the Girl. Leon arrives as Victor infects the staff and patients with a mutated strain of the T-virus, transforming them into zombies, and seals the facility, separating Grace and Leon. Grace navigates the hospital and frees a young blind girl named Emily. Grace and Leon learn that Victor is obsessed with obtaining Elpis—a bioweapon created by his deceased mentor Oswell Spencer—and that Grace is somehow essential to accomplishing this. Grace attempts to escape with Emily, but Emily is gravely wounded in the process. Grace kills the Girl by exposing her to daylight, but Emily mutates into a monster, and Leon seemingly kills her, devastating Grace. She abandons Leon and leaves the facility with Victor and his benefactor, a representative of the Connections named Zeno.
Leon and Sherry track Grace, Victor, and Zeno to the quarantined ruins of Raccoon City. Zeno tells Grace that, based on Victor's interpretation of Oswell's incomplete research, he believes Elpis is Oswell's ultimate weapon—a highly contagious mind-control virus—and that Emily is one of many clones of Grace created during experiments to transfer Oswell's consciousness into a new body. Zeno reveals that the government missile strike used to destroy Raccoon City after the original outbreak was orchestrated by the Connections not to eliminate the infection but to conceal Elpis. He brings Grace to ARK, a former Umbrella facility hidden beneath the destroyed city. Meanwhile, Victor attacks Leon but is apparently killed.
Inside ARK, Zeno explains that Elpis is protected by a self-destruct fail-safe if an incorrect password is entered. He believes Grace is the successful result of Oswell's consciousness-transfer experiments and therefore knows the code. Leon rescues her, but they become separated as his infection worsens. Grace accesses a terminal and views the contents of her mother's disk, which contains recorded interviews Alyssa conducted with Oswell. He expresses regret for the damage caused by his creations and reveals that he adopted Grace as an infant—a normal child unrelated to the cloning experiments—before entrusting her to Alyssa. Realizing that Spencer's final hope lay in her, Grace deduces that the password is "hope".
Leon and Grace reunite and confront Zeno in the Elpis chamber. Grace unlocks Elpis, a potent antiviral capable of neutralizing all viral weapons. Unaware, Zeno injects himself with Elpis, inadvertently removing his enhanced abilities, while Grace uses it to cure Leon's infection. Victor returns, kills Zeno and, misinterpreting Oswell's intentions, vows to use Elpis to sow chaos and upend the world order. Victor activates ARK's self-destruct system, mutates into a Nemesis-like monster, and is killed by Leon. Leon and Grace are rescued by the BSAA's Hound Wolf Squad, dispatched by Chris Redfield.
ARK's exposure sparks a global scandal and new investigations into Umbrella, the Connections, and the United States government. Some time later, Grace has cured Emily with Elpis and adopted her, while Sherry is also cured of RCS. In the ruins of ARK, soldiers from an unidentified faction eliminate the remaining BSAA forces and retrieve their objective.