Comix Zone

Comix Zone is set within a comic book of the same name, with the comic itself being set on a post-apocalyptic Earth. Each level is set in a different part of the comic world, such as a decimated New York City, the Himalayas, and the atolls of Zealand. The player controls Sketch Turner, a comic writer/artist who created the comic after dreaming vividly about its contents. While working on Comix Zone during a thunder-storm, Sketch's comic is hit by a lightning bolt, causing the book's antagonist, a mutant named Mortus, to escape its pages. Desiring a physical form in the real world, Mortus sends Sketch into the comic in the hopes of killing him and receiving a body in the process. Upon being transported, Sketch is met by Alissa Cyan, a defense force general fighting against Mortus who believes that Sketch came to save her world. Sketch disputes this fact, but regardless decides to go on Alissa's mission.
The duo traverse through the comic world for a while, defeating many of Mortus's henchmen along the way, until eventually reaching a weapons factory containing a nuclear weapon hidden on a derelict ship. As Alissa attempts to defuse the weapon, Mortus comes back into the comic and throws her into a chamber of rising liquid. Sketch manages to successfully defeat Mortus, frees Alissa from the chamber, and escapes the comic with her just as the weapon self-detonates. Now in the real world, Alissa enlists in the army and, after months, is promoted to Chief of Security for the United States. Comix Zone becomes the best-selling comic book ever, selling out on the first day and making him a celebrity overnight. Alissa moves in with Sketch and they live happily together.